UPDATE: People Magazine has reported that a source close to the family says Arquette died of AIDS-related complications.
 
Aalexislexis Arquette, one of the famed Arquette acting family whose siblings include Academy Award-winner Patricia and Scream star David, has died at age 47, her brother Richmond confirmed this morning. Alexis was surrounded by family after “battling an illness,” although no specific cause of death was given. The death, Richmond reported, was “fast and painless.”
Alexis, born Robert, came to prominence first as an actor, most notably in the Adam Sandler comedy The Wedding Singer. She was one of the most prominent and earliest entertainment celebrities to identify as trans. Alexis officially came out as transgender and documented her transition in the 2007 documentary Alexis Arquette: She’s My Brother. In addition, Alexis was a singer and activist on GLBT issues.